3-羟基-4-甲基-2(5H)-噻吩酮合成路线 （共 7 条）
反应条件
hydrogenchloride in water T=75°C;
参考文献
Hendrix; Roets; Bervoets; Thomas; Pijcke; Busson; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 4 p. 215 - 219
反应条件
2: 45 percent / 6N HCl / H2O / 75 °C View Scheme
参考文献
Hendrix; Roets; Bervoets; Thomas; Pijcke; Busson; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 4 p. 215 - 219
反应条件
1: 96 percent / Et3N / acetonitrile / 6 h 2: 1.) acetic anhydride, 2.) trifluoroacetic acid, 3.) anion exchange resin Bio-Rad AG-3, 200-400 mesh / 1.) pyridine, r.t., 12 h, 2.) 12 h 3: 45 percent / 6N HCl / H2O / 75 °C View Scheme
参考文献
Hendrix; Roets; Bervoets; Thomas; Pijcke; Busson; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 4 p. 215 - 219
反应条件
1: 1.) acetic anhydride, 2.) trifluoroacetic acid, 3.) anion exchange resin Bio-Rad AG-3, 200-400 mesh / 1.) pyridine, r.t., 12 h, 2.) 12 h 2: 45 percent / 6N HCl / H2O / 75 °C View Scheme
参考文献
Hendrix; Roets; Bervoets; Thomas; Pijcke; Busson; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 4 p. 215 - 219
反应条件
Pseudomonas putida UV4 mutant strain 7 h;
参考文献
Boyd, Derek R; Sharma, Narain D; Gunaratne, Nimal; Haughey, Simon A; Kennedy, Martina A; Malone, John F; Allen, Christopher C; Dalton, Howard
Organic and biomolecular chemistry, 2003 , vol. 1, # 6 p. 984 - 994
反应条件
disodium hydrogenphosphate in water T=60°C; 1 h; pH 9.1;
参考文献
Tsuji; Nakashima; Deguchi; Nishide; Shimizu; Horiuchi; Ishikawa; Yamana
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 10 p. 1120 - 1128
参考文献
Hendrix; Roets; Roesems; Busson; Rozenski; Janssen; Hoogmartens
Archiv der Pharmazie, 1994 , vol. 327, # 12 p. 805 - 807
