1-(二氟甲氧基)-4-氟苯合成路线 （共 5 条）
反应条件
difluoro[4-(trifluoromethyl)phenyl]-λ(3)-bromane in chloroform T=20°C; 2 h; Inert atmosphere;
参考文献
Ochiai, Masahito; Yoshimura, Akira; Hoque, Md. Mahbubul; Okubo, Takuji; Saito, Motomichi; Miyamoto, Kazunori
Organic Letters, 2011 , vol. 13, # 20 p. 5568 - 5571
反应条件
potassium hydroxide in acetonitrile T=80°C; 4 h;
参考文献
Zhang, Laijun; Zheng, Ji; Hu, Jinbo
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9845 - 9848
反应条件
1: With sodium hydroxide in water 0.0833333 h; Inert atmosphere; 2: With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in water 2.5 h; Inert atmosphereUV-irradiation;
参考文献
Leung, Joe C. T.; Chatalova-Sazepin, Claire; West, Julian G.; Rueda-Becerril, Montserrat; Paquin, Jean-Francois; Sammis, Glenn M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 43 p. 10804 - 10807
Angewandte Chemie, 2012 , vol. 124, # 43 p. 10962 - 10965
反应条件
1.1: sodium hydroxide; water / methanol / 2 h / 20 °C / |Inert atmosphere 1.2: pH < 2 - 7 / |Inert atmosphere 2.1: sodium hydroxide / water / 0.08 h / |Inert atmosphere 2.2: 2.5 h / |Inert atmosphere; |UV-irradiation View Scheme
参考文献
Leung, Joe C. T.; Chatalova-Sazepin, Claire; West, Julian G.; Rueda-Becerril, Montserrat; Paquin, Jean-Francois; Sammis, Glenn M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 43 p. 10804 - 10807
Angewandte Chemie, 2012 , vol. 124, # 43 p. 10962 - 10965
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / |Inert atmosphere 2.1: sodium hydroxide; water / methanol / 2 h / 20 °C / |Inert atmosphere 2.2: pH < 2 - 7 / |Inert atmosphere 3.1: sodium hydroxide / water / 0.08 h / |Inert atmosphere 3.2: 2.5 h / |Inert atmosphere; |UV-irradiation View Scheme
参考文献
Leung, Joe C. T.; Chatalova-Sazepin, Claire; West, Julian G.; Rueda-Becerril, Montserrat; Paquin, Jean-Francois; Sammis, Glenn M.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 43 p. 10804 - 10807
Angewandte Chemie, 2012 , vol. 124, # 43 p. 10962 - 10965
