4-(4-氟-3-甲基-苯基)-4-氧代-丁酸合成路线 （共 5 条）
反应条件
aluminium trichloride
参考文献
Journal of Organic Chemistry, , vol. 22, p. 193,195
反应条件
Jone's reagent in acetone T=20°C; 0.5 h;
参考文献
US2010/286125 A1, ;
Page/Page column 20 ;
反应条件
1: 1-bromo-4-fluoro-3-methylbenzene With iodine; magnesium in tetrahydrofuran T=62°C; 2: succinic acid anhydride in tetrahydrofuran T=-70 - 20°C; 3 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
US2010/286125 A1, ;
Page/Page column 15 ;
反应条件
hydrogenchloride; aluminium trichloride
反应条件
potassium hydroxide; hydrazine hydrate; diethylene glycol
参考文献
Daiichi Pharmaceutical Co., Ltd.; Kabushikikaisha Yakult Honsha
Patent: US5849945 A1, 1998 ;
