3-硝基-5-(三氟甲基)苯酚合成路线 （共 12 条）
反应条件
hydrogen bromide; acetic acid in water Heating / reflux;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2006/160803 A1, 2006 ;
Location in patent: Page/Page column 138 ;
US 20060160803 A1
反应条件
KNO2 in N,N-dimethyl-formamide T=130 - 140°C; 20 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
3,5-Dinitrobenzotrifluoride; potassium carbonate in N,N-dimethyl-formamide T=85 - 145°C; 17 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
potassium carbonate in N,N-dimethyl-formamide T=85 - 145°C; 17 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
KNO2 in N,N-dimethyl-formamide T=130 - 140°C; 20 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
potassium carbonate in N,N-dimethyl-formamide T=130 - 140°C; 17 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
1: 69 percent / NaI, glacial acetic acid / acetone / 24 h / 63 - 65 °C 2: 77 percent / KF, o-phthaloyl dichloride / tetrahydrothiophene 1,1-dioxide / 24 h / 180 - 200 °C 3: 40 percent / KNO2 / dimethylformamide / 20 h / 130 - 140 °C 4: KNO2 / dimethylformamide / 20 h / 130 - 140 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
1: 51 percent / KNO2 / dimethylformamide / 20 h / 130 - 140 °C 2: 3 percent / KNO2 / dimethylformamide / 20 h / 130 - 140 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
1: 77 percent / KF, o-phthaloyl dichloride / tetrahydrothiophene 1,1-dioxide / 24 h / 180 - 200 °C 2: 40 percent / KNO2 / dimethylformamide / 20 h / 130 - 140 °C 3: KNO2 / dimethylformamide / 20 h / 130 - 140 °C View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 9 p. 1325 - 1331
反应条件
sulfuric acid Diazotization.Eintragen der Diazoniumsalz-Loesung in siedende wss. CuSO4-Loesung;
参考文献
Journal of the Chemical Society, , p. 3016,3019
