4-(乙酰基氨基)-3-氟苯磺酰氯合成路线 （共 5 条）
反应条件
1: With trichlorophosphate T=0 - 20°C; 15.5 h; 2: With water T=0°C; 0.25 h;
参考文献
Astrazeneca AB
Patent: US6667342 B1, 2003 ;
Location in patent: Page column 70-71 ;
US 6667342 B1
反应条件
1: 100 percent / 0.5 h / Heating 2: chlorosulfonic acid / 3 h / 70 °C View Scheme
参考文献
Boehringer Ingelheim Vetmedica GmbH
Patent: US4624960 A1, 1986 ;
反应条件
chlorosulfonic acid T=70°C; 3 h;
参考文献
Patel, Pratik R.; Ramalingan, Chennan; Park, Yong-Tae
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6610 - 6614
反应条件
1: aq. NH4OH / 0.5 h / 70 °C 2: aq. HCl / 0.75 h / Heating View Scheme
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
反应条件
ammonium hydroxide
T=70°C; 0.5 h;
参考文献
Ilies, Marc A.; Vullo, Daniela; Pastorek, Jaromir; Scozzafava, Andrea; Ilies, Monica; Caproiu, Miron T.; Pastorekova, Silvia; Supuran, Claudiu T.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2187 - 2196
