N-甲基-2-(3,4-二甲氧基苯基)乙胺合成路线 （共 52 条）
参考文献
Helvetica chimica acta, , vol. 58, # 7 p. 2050 - 2060
参考文献
Journal of the Chemical Society, , p. 3926,3931
反应条件
formic acid T=210°C; Erhitzen des Reaktionsprodukts in Toluol mit Phosphor(V)-oxid und Behandeln des danach erhaltenen Reaktionsprodukts mit wss.Natronlauge;
参考文献
Buck
Journal of the American Chemical Society, 1930 , vol. 52, p. 4119,4121
反应条件
potassium carbonate in N,N-dimethyl-formamide 16 h; Ambient temperature;
参考文献
Kali-Chemie Pharma GmbH
Patent: US5547967 A1, 1996 ;
反应条件
Rapp TentaGel S RAM resin; water; tris-(o-tolyl)phosphine; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) 1.) EDC, DMF; 2.) dioxane, 70-80 deg C, 16-20 h; 3.) 40 min; Yield given. Multistep reaction;
参考文献
Willoughby, Christopher A.; Chapman, Kevin T.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7181 - 7184
反应条件
Rapp TentaGel S RAM resin; water; tris-(o-tolyl)phosphine; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) 1.) EDC, DMF; 2.) dioxane, 70-80 deg C, 16-20 h; 3.) 40 min; Yield given. Multistep reaction;
参考文献
Willoughby, Christopher A.; Chapman, Kevin T.
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7181 - 7184
反应条件
sodium carbonate in benzene
参考文献
Runge et al.
Patent: DD122967 , 1976 ;
Chem.Abstr., 1977 , vol. 87, # 134458
反应条件
1: 3-nitro-phenyl boronic acid / anhydrous xylene / 24 h / 40 °C / |Reflux 2: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 0 - 25 °C View Scheme
参考文献
Bannister, Robin M.; Brookes, Michael H.; Evans, Graham R.; Katz, Ruth B.; Tyrrell, Nicholas D.
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 467 - 472
反应条件
formic acid; palladium on activated charcoal in ethanol T=100°C; 18 h;
参考文献
Wu, Lingyun; Hartwig, John F.
Journal of the American Chemical Society, 2005 , vol. 127, # 45 p. 15824 - 15832
反应条件
hydrogen; palladium monocarbide in ethyl acetate; isopropyl alcohol
参考文献
Ludwig Heumann and Co., GmbH
Patent: US4697035 A1, 1987 ;
