N-甲基-2-(3,4-二甲氧基苯基)乙胺合成路线 (共 52 条)
反应条件
1: bromine / acetic acid
2: copper diacetate; palladium diacetate; potassium carbonate / toluene / 24 h / Inert atmosphere; Reflux
View Scheme
参考文献
Harada, Rika; Nishida, Naoto; Uchiito, Shiho; Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Masao, Tokuda; Ohkuma, Takeshi; Orito, Kazuhiko
European Journal of Organic Chemistry, 2012 , # 2 p. 366 - 379
反应条件
1: 40 percent / t-BuOK / dimethylsulfoxide / 2 h / 50 °C
View Scheme
参考文献
Pauvert, Mickael; Collet, Sylvain; Guingant, Andre
Tetrahedron Letters, 2003 , vol. 44, # 22 p. 4203 - 4206
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Singh, Kawaljit; Kumar, Malkeet; Pavadai, Elumalai; Naran, Krupa; Warner, Digby F.; Ruminski, Peter G.; Chibale, Kelly
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 2985 - 2990
参考文献
Buck; Baltzly
Journal of the American Chemical Society, 1942 , vol. 64, p. 2263
反应条件
sodium tetrahydroborate; toluene-4-sulfonic acid
1) benzene, reflux, 2) MeOH; Multistep reaction;
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
反应条件
1: 1) p-TsOH, 2) NaBH4 / 1) benzene, reflux, 2) MeOH
2: 48 percent HBr / 3 h / Heating
View Scheme
参考文献
Casagrande; Santangelo; Saini; Doggi; Gerli; Cerri
Arzneimittel-Forschung/Drug Research, 1986 , vol. 36, # 2 A p. 291 - 303
参考文献
Brenna, Elisabetta; Fuganti, Claudio; Grasselli, Piero; Serra, Stefano
European Journal of Organic Chemistry, 2001 , # 7 p. 1349 - 1357
反应条件
in tetrahydrofuran
T=80°C; 48 h; Yield given;
参考文献
Theodore; Nelson
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1309 - 1315
反应条件
T=210°C; Erwaermen des Reaktionsprodukts in Benzol mit Thionylchlorid und Erhitzen des erhaltenen kristallinen Reaktionsprodukts auf 140grad unter vermindertem Druck;
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
Full Text Show Details
Hjort et al.
Journal of Pharmacology and Experimental Therapeutics, 1942 , vol. 76, p. 263,264