(E)-3-(甲基苯基氨基)-2-丙烯醛合成路线 （共 9 条）
反应条件
1: With bis(trichloromethyl) carbonate in 1,4-dioxane T=10 - 20°C; 2: With sodium hydroxide in tert-butyl methyl ether; water T=5 - 10°C; pH=7;
参考文献
Clariant Life Science Molecules (Italia) SpA
Patent: EP1477474 A1, 2004 ;
Location in patent: Page column 3 - 4 ;
反应条件
manganese(IV) oxide in toluene Inert atmosphere;
参考文献
Sun, Qi; Wu, Runzhi; Cai, Sutang; Lin, Yuan; Sellers, Llewlyn; Sakamoto, Kaori; He, Biao; Peterson, Blake R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1126 - 1139
反应条件
1: With trichlorophosphate in acetonitrile T=5 - 60°C; 4.5 - 7 h; 2: With water T=60°C; 1 h;
参考文献
Clariant Life Science Molecules (Italia) SpA
Patent: EP1477474 A1, 2004 ;
Location in patent: Page column 5 - 6 ;
反应条件
T=800°C; P=0.005 Torr; 0.333333 h; Further byproducts given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 339 - 342
反应条件
1: zirconium tetrachloride / ethanol / 0.5 h / 80 °C / Inert atmosphere 2: manganese(IV) oxide / 0.08 h / 22 °C / Inert atmosphere 3: 24 h / 75 °C / Inert atmosphere View Scheme
参考文献
Sun, Qi; Wu, Runzhi; Cai, Sutang; Lin, Yuan; Sellers, Llewlyn; Sakamoto, Kaori; He, Biao; Peterson, Blake R.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 5 p. 1126 - 1139
反应条件
T=800°C; P=0.005 Torr; 0.333333 h; Further byproducts given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 339 - 342
反应条件
in water; acetonitrile
参考文献
Sandoz Ltd.
Patent: US5118853 A1, 1992 ;
反应条件
T=800°C; P=0.005 Torr; 0.333333 h; Further byproducts given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 339 - 342
反应条件
trichlorophosphate in tetrahydrofuran T=-10°C; Substitution; 2 h;
参考文献
Gromov; Sergeev; Druzhinin; Rusalov; Uzhinov; Kuz'mina; Churakov; Howard; Alfimov
Russian Chemical Bulletin, 1999 , vol. 48, # 3 p. 525 - 536
