2,2-二甲基四氢吡喃-4-甲醛合成路线 （共 8 条）
反应条件
hydrogenchloride in water T=90°C; 4 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 58-59 ;
WO 2004/058763 A1
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane T=20°C; 2 h; Molecular sieveInert atmosphere;
参考文献
WO2012/66070 A1, ;
Page/Page column 108 ;
WO 2012/066070 A1
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 13 p. 3692 - 3695
反应条件
potassium permanganate; water in water T=25°C; 6 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 58-59 ;
WO 2004/058763 A1
反应条件
1: 1) Magnesium, 3) 18percent hydrochloric acid / 2) Ether, 5 deg C, 4 h, 3) 0 deg C.
2: 79 percent / Potassium bichromate, 14percent sulfuric acid / 4 h / 50 °C
View Scheme
参考文献
Kuroyan, R. A.; Markosyan, A. I.; Engoyan, A. P.; Vartanyan, S. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 12 p. 2219 - 2221
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 12 p. 2591 - 2594
反应条件
1: sodium ethoxide / benzene / 5 h / 60 - 65 °C
2: aq.NaOH / 3 h / 75 - 80 °C
3: 3 h / 200 - 220 °C
View Scheme
参考文献
Kuroyan, R. A.; Markosyan, A. I.; Engoyan, A. P.; Vartanyan, S. A.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1709 - 1714
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1947 - 1953
反应条件
1: sodium ethoxide / benzene / 5 h / 60 - 65 °C
2: aq.NaOH / 3 h / 75 - 80 °C
3: 3 h / 200 - 220 °C
View Scheme
参考文献
Kuroyan, R. A.; Markosyan, A. I.; Engoyan, A. P.; Vartanyan, S. A.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 1709 - 1714
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 9 p. 1947 - 1953
反应条件
1: With sodium tetrahydroborate in ethanol
T=0 - 50°C; 3 h;
2: With ethanol
Acidic conditions;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/101867 A1, 2008 ;
Location in patent: Page/Page column 91 ;
