2-氯-4-氟吡啶合成路线

参考文献

Kuduk, Scott D.; DiPardo, Robert M.; Bock, Mark G.
Organic Letters, 2005 , vol. 7, # 4 p. 577 - 579

参考文献

MERCK SHARP and DOHME CORP.; LIU, Jian; BALKOVEC, James, M.; KRIKORIAN, Arto, D.; GUIADEEN, Deodial; YANG, Ginger; JIAN, Tianying; WU, Zhicai; YU, Yang; NARGUND, Ravi, P.; VACHAL, Petr; DEVITA, Robert, J.; HE, Shuwen; LAI, Zhong; BLEVIS-BAL, Radhika, M.; CERNAK, Timothy, A.; SPERBECK, Donald, M.; HONG, Qingmei
Patent: WO2012/96813 A1, 2012 ;
WO 2012/096813 A1

34941-91-82-氯-4-氟吡啶

944401-77-82-氨基-4-氟吡啶

参考文献

UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning
Patent: WO2014/9295 A1, 2014 ;

34941-91-82-氯-4-氟吡啶+

5188-07-8甲硫醇钠

71506-83-72-氯-4-甲硫基吡啶

参考文献

WYETH
Patent: WO2008/49047 A2, 2008 ;
Location in patent: Page/Page column 114 ;

56-23-5四氯化碳+

34941-91-82-氯-4-氟吡啶

34415-32-22,3,5,6-四氯-4-氟吡啶

参考文献

Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148

34941-91-82-氯-4-氟吡啶+

124-38-9二氧化碳

929022-76-42-氯-4-氟烟酸

参考文献

MERCK SHARP and DOHME CORP.; BUNGARD, Christopher, James; PERKINS, James, J.; MANIKOWSKI, Jesse, J.; DE LEON, Pablo; MEISSNER, Robert, S.
Patent: WO2011/53574 A1, 2011 ;
Location in patent: Page/Page column 44 ;

34941-91-82-氯-4-氟吡啶

944401-69-85-溴-4-氟吡啶-2-胺

参考文献

UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning
Patent: WO2014/9295 A1, 2014 ;