7-溴-3,4-二氢-2H-吡啶并[3,2-b]-1,4-噁嗪合成路线 (共 4 条)
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
EP2341052 A1, ;
Page/Page column 40 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in water; tert-butyl alcohol T=85°C; 4 h; Inert atmosphere;
参考文献
Zhang, Dengyou; Sun, Haifeng; Zhang, Lei; Zhou, Yu; Li, Chunpu; Jiang, Hualiang; Chen, Kaixian; Liu, Hong
Chemical Communications, 2012 , vol. 48, # 23 p. 2909 - 2911
反应条件
1-methyl-pyrrolidin-2-one
参考文献
Clauson-Kaas,N. et al.
Acta Chemica Scandinavica (1947-1973), 1971 , vol. 25, p. 3135 - 3143
反应条件
potassium carbonate; tri-cyclo-hexyl-phosphine; palladium diacetate in water; toluene T=115°C; Suzuki Coupling; 96 h; Inert atmosphereSealed tube;
参考文献
WO2012/75316 A2, ;
Page/Page column 55 ;