4'-乙酰氨基-2'-甲基苯乙酮合成路线 （共 5 条）
反应条件
1: N-(3-methylphenyl)acetamide With AlCl3, aluminium chloride in dichloromethane T=0 - 10°C; 2: acetyl chloride in dichloromethane T=20°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/138472 A2, 2007 ;
Location in patent: Page/Page column 35-36 ;
反应条件
lithium perchlorate; gallium trifluoromethanesulfonate in nitromethane T=50°C; Friedel-Crafts acylation; 24 h;
参考文献
Japan Science and Technology Corporation
Patent: EP1359141 A1, 2003 ;
Location in patent: Page/Page column 6-7 ;
反应条件
aluminium trichloride
参考文献
Journal of the Indian Chemical Society, , vol. 33, p. 867,869
Journal of Organic Chemistry, , vol. 17, p. 1463
Bulletin of the Chemical Society of Japan, , vol. 30, p. 958,960
参考文献
Edgar, Dale M.; Hangauer, David G.; White, James F.; Solomon, Michael
Patent: US2005/143348 A1, 2005 ;
Location in patent: Page/Page column 51 ;
US 20050143348 A1
反应条件
sulfur T=110 - 130°C;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/138472 A2, 2007 ;
Location in patent: Page/Page column 35-37 ;
