N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯合成路线 （共 17 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=0 - 5°C; 3 h;
参考文献
Becerril, Jorge; Bolte, Michael; Burguete, M. Isabel; Galindo, Francisco; Garcia-Espana, Enrique; Luis, Santiago V.; Miravet, Juan F.
Journal of the American Chemical Society, 2003 , vol. 125, # 22 p. 6677 - 6686
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile 4 h; Ambient temperature;
参考文献
Takeda; Ayabe; Suzuki; Konda; Harigaya
Synthesis, 1991 , # 9 p. 689 - 691
反应条件
pyridine in acetonitrile 5 h;
参考文献
Tetrahedron Letters, , vol. 24, # 41 p. 4451 - 4454
反应条件
triethylamine in tetrahydrofuran; water T=24°C; 0.5 h;
参考文献
Sosnovsky; Prakash; Rao
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 1 - 10
反应条件
1: 61 percent / Et3N / tetrahydrofuran; H2O / 24 h / Ambient temperature 2: 96 percent / acetic acid, H2 / Pd black View Scheme
参考文献
Shigenaga; Otagiri; Kanehisa; Okai
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 1 p. 103 - 107
反应条件
triethylamine in tetrahydrofuran
参考文献
Beacham,J. et al.
Journal of the American Chemical Society, 1971 , vol. 93, p. 5526 - 5539
反应条件
1: 78 percent / Et3N / tetrahydrofuran; H2O / 20 °C 2: H2 / Pd/C / methanol / 3 h / 25 °C / 1551.49 Torr View Scheme
参考文献
Ganellin, C. Robin; Bishop, Paul B.; Bambal, Ramesh B.; Chan, Suzanne M. T.; Law, James K.; Marabout, Benoit; Luthra, Pratibha Mehta; Moore, Andrew N. J.; Peschard, Olivier; Bourgeat, Pierre; Rose, Christiane; Vargas, Froylan; Schwartz, Jean-Charles
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 664 - 674
反应条件
ammonia in chloroform T=0 - 20°C; ammonolysis; 1.25 h;
参考文献
Sawa, Eiji; Takahashi, Motoo; Kamishohara, Masaru; Tazunoki, Tetsushi; Kimura, Kaname; Arai, Midori; Miyazaki, Tetsuko; Kataoka, Shiro; Nishitoba, Tsuyoshi
Journal of Medicinal Chemistry, 1999 , vol. 42, # 17 p. 3289 - 3299
反应条件
1: 25 percent / ammonia / CHCl3 / 1.25 h / 0 - 20 °C 2: 100 percent / POCl3; pyridine / 1.5 h / -15 °C View Scheme
参考文献
Sawa, Eiji; Takahashi, Motoo; Kamishohara, Masaru; Tazunoki, Tetsushi; Kimura, Kaname; Arai, Midori; Miyazaki, Tetsuko; Kataoka, Shiro; Nishitoba, Tsuyoshi
Journal of Medicinal Chemistry, 1999 , vol. 42, # 17 p. 3289 - 3299
