2-吡啶-4-苯并噁唑-5-胺合成路线 （共 4 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol; ethyl acetate T=20°C; 6 h; Inert atmosphere;
参考文献
BRANDEIS UNIVERSITY; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; HEDSTROM, Lizbeth, K.; CUNY, Gregory, D.; GORLA, Suresh, Kumar; KAVITHA, Mandapati
Patent: WO2014/28931 A2, 2014 ;
Location in patent: Page/Page column 139 ;
反应条件
1: triethylamine / tetrahydrofuran / 3 h / Heating 2: H2SO4 / xylene / 24 h / Heating 3: H2 / PtO2 / ethanol / 2585.7 Torr View Scheme
参考文献
BRANDEIS UNIVERSITY; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; HEDSTROM, Lizbeth, K.; CUNY, Gregory, D.; GORLA, Suresh, Kumar; KAVITHA, Mandapati
Patent: WO2014/28931 A2, 2014 ;
反应条件
1: triethylamine / tetrahydrofuran / 3 h / Heating 2: H2SO4 / xylene / 24 h / Heating 3: H2 / PtO2 / ethanol / 2585.7 Torr View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
反应条件
1: oxygen; carbon / anhydrous xylene / 4 h / 120 °C / |Inert atmosphere 2: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 6 h / 20 °C / |Inert atmosphere View Scheme
参考文献
BRANDEIS UNIVERSITY; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; HEDSTROM, Lizbeth, K.; CUNY, Gregory, D.; GORLA, Suresh, Kumar; KAVITHA, Mandapati
Patent: WO2014/28931 A2, 2014 ;
