反应条件
1.1: thionyl chloride / toluene / 60 - 75 °C 2.1: 1-methyl-pyrrolidin-2-one / 0.67 h / 20 °C 2.2: 3 h / 40 °C 3.1: potassium carbonate; copper / N,N-dimethyl-formamide / 1 h / Reflux 4.1: sodium hydroxide / methanol / 6 h / Reflux View Scheme
参考文献
MYREXIS, INC.; KUMAR, Dange Vijay; SLATTUM, Paul M.; YAGER, Kraig M.; SHENDEROVICH, Mark D.; TANGALLAPALLY, Rajendra; KIM, Se-Ho
Patent: WO2012/177782 A1, 2012 ;
WO 2012/177782 A1
