3,3-二甲基环丁烷甲酸合成路线 （共 18 条）
反应条件
1: saponification 2: 180 °C View Scheme
参考文献
Park; Varick; Newcomb
Tetrahedron Letters, 1990 , vol. 31, # 21 p. 2975 - 2978
反应条件
1: lithium aluminium hydride 2: pyridine / 2 h / Ambient temperature 3: lithium bromide / acetone / Ambient temperature 4: 1.) magnesium / in THF View Scheme
参考文献
Hill, Alexander E.; Link, Daniel C.; Donndelinger Peter
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1177 - 1182
参考文献
PFIZER INC.; DIDIUK, Mary; FILIPSKI, Kevin J.; GUZMAN-PEREZ, Angel; LEE, Esther C.; PFEFFERKORN, Jeffrey A.; STEVENS, Benjamin; TU, Meihua
Patent: WO2013/14569 A1, 2013 ;
Location in patent: Page/Page column 37 ;
WO 2013/014569 A1
反应条件
1: SOCl2 2: benzene 3: LiAlH4 / diethyl ether / Heating 4: (i) H2O2, (ii) (pyrolysis) 5: O3, Py / CH2Cl2 View Scheme
参考文献
Conia,J.-M.; Gore,J.
Bulletin de la Societe Chimique de France, 1963 , p. 735 - 743
反应条件
lithium aluminium tetrahydride in diethyl ether
Heating;
参考文献
Hill, Alexander E.; Link, Daniel C.; Donndelinger Peter
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1177 - 1182
反应条件
1: lithium aluminium hydride
2: pyridine / 2 h / Ambient temperature
3: lithium bromide / acetone / Ambient temperature
View Scheme
参考文献
Hill, Alexander E.; Link, Daniel C.; Donndelinger Peter
Journal of Organic Chemistry, 1981 , vol. 46, # 6 p. 1177 - 1182
反应条件
acetic acid in methanol; acetonitrile
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/212960 A1, 2011 ;
Location in patent: Page/Page column 32-33 ;
反应条件
1: SOCl2
2: (i), (ii) /BRN= 605257/
3: LiAlH4 / diethyl ether
4: (pyrolysis)
View Scheme
参考文献
Bruckmann,P.; Klessinger,M.
Chemische Berichte, 1974 , vol. 107, p. 1108 - 1125
