1-(3,4-二甲氧基苯基)-1-氨基甲基环戊烷合成路线 (共 2 条)
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 16 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/49018 A1, 2005 ;
Location in patent: Page/Page column 84-85 ;
WO 2005/049018 A1
反应条件
1: 1-(3,4-dimethoxy-phenyl)-cyclopentanecarbonitrile With lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; 16 h; 2: 4-chloro-butyl chloride in tetrahydrofuran 40 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/35514 A2, 2005 ;
Location in patent: Page/Page column 114-115 ;
WO 2005/035514 A2