in methanol 12 h; Heating;

1.1: Neat (no solvent) 2.1: ammonium formate / palladium 10 on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice 3.1: toluene / -20 °C / Inert atmosphere; Reflux 4.1: tris(n-butyl)phosphine oxide; lithium bromide / o-xylene / 1 h / Reflux 5.1: hydrogenchloride; water / 0.25 h / 20 °C 5.2: pH 8 - 9 View Scheme

1.1: Neat (no solvent) 2.1: ammonium formate / palladium 10 on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice 3.1: toluene / -20 °C / Inert atmosphere; Reflux 4.1: tris(n-butyl)phosphine oxide; lithium bromide / o-xylene / 1 h / Reflux 5.1: hydrogenchloride; water / 0.25 h / 20 °C 5.2: pH 8 - 9 6.1: dichloromethane; water / 1 h / 20 °C 6.2: pH 9 / cooling with ice View Scheme

1: Neat (no solvent) 2: ammonium formate / palladium 10 on activated carbon / tetrahydrofuran; methanol / 20 °C / Inert atmosphere; cooling with ice 3: sodium hydrogencarbonate / water View Scheme

Neat (no solvent);