4-氟-Alpha-甲基苯乙烯合成路线 （共 27 条）
反应条件
1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in tetrahydrofuran T=0°C; 1 h; 2: 1-fluoro-4-acetyl-benzene in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: US2008/15237 A1, 2008 ;
Location in patent: Page/Page column 27 ;
US 20080015237 A1
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=0°C; 1 h; 2: 1-fluoro-4-acetyl-benzene in tetrahydrofuran Wittig olefination; Further stages.;
参考文献
Sherrill, William M.; Kim, Ryan; Rubin, Michael
Tetrahedron, 2008 , vol. 64, # 37 p. 8610 - 8617
参考文献
Journal of Organic Chemistry, , vol. 34, p. 3312 - 3315
反应条件
[2,2']bipyridinyl; tetra-n-butylammonium tetrafluoroborate; cobalt(II) dibromide in pyridine; acetonitrile T=20°C; Electrolysis;
参考文献
Gomes, Paulo; Gosmini, Corinne; Perichon, Jacques
Tetrahedron, 2003 , vol. 59, # 17 p. 2999 - 3002
反应条件
n-tridecane; [NiCl2(PMe3)2] in tetrahydrofuran T=60°C;
参考文献
Tetrahedron Letters, , vol. 44, # 9 p. 1907 - 1910
反应条件
formaldehyd; N-methylamine hydrochloride
反应条件
[NiCl2(PMe3)2] in tetrahydrofuran T=60°C;
参考文献
Miller, Joseph A.; Dankwardt, John W.; Penney, Jonathan M.
Synthesis, 2003 , # 11 p. 1643 - 1648
反应条件
2,4-dinitrobenzenesulfonic acid hydrate in acetonitrile T=80°C; 24 h; Title compound not separated from byproducts.;
参考文献
European Journal of Organic Chemistry, , # 28 p. 4642 - 4645
反应条件
diethyl ether Kochen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Jod in Toluol;
参考文献
Journal of the American Chemical Society, , vol. 70, p. 1177
反应条件
1: Ph3P(1+)MeI With potassium tert-butylate in tetrahydrofuran T=20°C; 2 h; 2: 1-fluoro-4-acetyl-benzene in tetrahydrofuran T=20°C; 2.5 h;
参考文献
Chemistry - A European Journal, , vol. 18, # 49 p. 15816 - 15821
