1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C
1.2: 16 h / 20 °C
2.1: lithium hydroxide hydrate; methanol / tetrahydrofuran / 12 h
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; CORTE, James R.
Patent: WO2013/55984 A1, 2013 ;
