[(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代嘧啶-1-基)四氢呋喃-2-基]甲基[(2R,3S,5R)-2-(羟基甲基)-5-(5-甲基-2,4-二氧代嘧啶-1-基)四氢呋喃-3-基]甲基磷酸酯合成路线 （共 13 条）
反应条件
trifluoroacetic acid in dichloromethane T=0°C; 0.166667 h;
参考文献
Jankowski, Aleksander; Golankiewicz, Krzysztof
Polish Journal of Chemistry, 1982 , vol. 56, # 10-12 p. 1563 - 1568
参考文献
Misiura, Konrad; Szymanowicz, Daria; Kunierczyk, Halina
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1525 - 1532
反应条件
1.1: DBU / acetonitrile / 0.25 h 1.2: 68 percent / acetonitrile / 2 h 2.1: 85 percent / aq. AgF / acetonitrile / 1 h 3.1: 53 percent / toluenesulfonic acid / CHCl3 / 0.08 h 4.1: 65 percent / Et3N / 1 h View Scheme
参考文献
Misiura, Konrad; Pietrasiak, Daria; Stec, Wojciech J.
Journal of the Chemical Society, Chemical Communications, 1995 , # 6 p. 613 - 614
反应条件
1.1: 1H-tetrazole / CH2Cl2 / 1 h 1.2: 77 percent / Se / CH2Cl2 / 12 h 2.1: DBU / acetonitrile / 0.25 h 2.2: 68 percent / acetonitrile / 2 h 3.1: 85 percent / aq. AgF / acetonitrile / 1 h 4.1: 53 percent / toluenesulfonic acid / CHCl3 / 0.08 h 5.1: 65 percent / Et3N / 1 h View Scheme
参考文献
Misiura, Konrad; Szymanowicz, Daria; Kunierczyk, Halina
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1525 - 1532
反应条件
1: 53 percent / toluenesulfonic acid / CHCl3 / 0.08 h 2: 65 percent / Et3N / 1 h View Scheme
参考文献
Misiura, Konrad; Szymanowicz, Daria; Kunierczyk, Halina
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1525 - 1532
反应条件
1: 85 percent / aq. AgF / acetonitrile / 1 h 2: 53 percent / toluenesulfonic acid / CHCl3 / 0.08 h 3: 65 percent / Et3N / 1 h View Scheme
参考文献
Misiura, Konrad; Szymanowicz, Daria; Kunierczyk, Halina
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 6 p. 1525 - 1532
反应条件
trifluoroacetic acid in methanol; dichloromethane 0.166667 h; Ambient temperature;
参考文献
Ohuchi, Shokichi; Ayukawa, Hiroshi; Hata, Tsujiaki
Chemistry Letters, 1992 , # 8 p. 1501 - 1504
反应条件
1: 0.1 M TRIS-HCl, pH 7.2 / 2 h 2: AgF / acetonitrile View Scheme
参考文献
Misiura, Konrad; Pietrasiak, Daria; Stec, Wojciech J.
Journal of the Chemical Society, Chemical Communications, 1995 , # 6 p. 613 - 614
反应条件
1: ethylenediamine / methanol / 6 h / Ambient temperature 2: trifluoroacetic acid / CH2Cl2; methanol / 0.17 h / Ambient temperature View Scheme
参考文献
Ohuchi, Shokichi; Ayukawa, Hiroshi; Hata, Tsujiaki
Chemistry Letters, 1992 , # 8 p. 1501 - 1504
反应条件
1: 1.) tributyltin chloride / 2.) CH2Cl2, RT, 12 h 2: ethylenediamine / methanol / 6 h / Ambient temperature 3: trifluoroacetic acid / CH2Cl2; methanol / 0.17 h / Ambient temperature View Scheme
参考文献
Ohuchi, Shokichi; Ayukawa, Hiroshi; Hata, Tsujiaki
Chemistry Letters, 1992 , # 8 p. 1501 - 1504
