(+)生物素-N-琥珀酰亚胺基酯合成路线 （共 14 条）
反应条件
dicyclohexyl-carbodiimide in N,N-dimethyl-formamide T=20°C;
参考文献
Journal of the American Chemical Society, , vol. 129, # 45 p. 13987 - 13996
反应条件
1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water; N,N-dimethyl-formamide 0.333333 h;
参考文献
WO2007/131286 A1, ;
Page/Page column 70 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 11 p. 1406 - 1410
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 6 h;
参考文献
Tetrahedron, , vol. 57, # 49 p. 9859 - 9866
反应条件
1: With sodium hydrogencarbonate in water; N,N-dimethyl-formamide 2: With ethylenediaminetetraacetic acid in water
参考文献
APOLLO LIFE SCIENCES LIMITED
Patent: WO2007/131286 A1, 2007 ;
Location in patent: Page/Page column 70 ;
反应条件
1: 1-amino-11-azido-3,6,9-trioxaundecane With triethylamine in N,N-dimethyl-formamide 0.5 h; 2: D-biotin-N-hydroxysuccinimide ester in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; KOHN, Harold, L.; PARK, Ki Duk
Patent: WO2010/14236 A2, 2010 ;
Location in patent: Page/Page column 35 ;
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; pH=8 - 8.5; Inert atmosphere;
参考文献
Shi, Haibin; Liu, Kai; Xu, Ashley; Yao, Shao Q.
Chemical Communications, 2009 , # 33 p. 5030 - 5032
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
Marchand-Brynaert, Jacqueline; Bouchet, Michele; Touillaux, Roland; Beauve, Cecile; Fastrez, Jacques
Tetrahedron, 1996 , vol. 52, # 15 p. 5591 - 5606
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Yamada, Michio; Harada, Kenji; Maeda, Yutaka; Hasegawa, Tadashi
New Journal of Chemistry, 2013 , vol. 37, # 11 p. 3762 - 3769
