(+)生物素-N-琥珀酰亚胺基酯合成路线 （共 14 条）
反应条件
sodium hydroxide in 1,4-dioxane T=20°C;
参考文献
Wang, Jun; Uttamchandani, Mahesh; Li, Ping Sun; Yao, Shao Q.
Chemical Communications, 2006 , # 7 p. 717 - 719
反应条件
N-ethyl-N,N-diisopropylamine in water; N,N-dimethyl-formamide 20 h; Ambient temperature;
参考文献
Finn, Frances M.; Yamanouchi, Keitaro; Titus, Gail; Hofmann, Klaus
Bioorganic Chemistry, 1995 , vol. 23, # 2 p. 152 - 168
反应条件
triethylamine in N,N-dimethyl-formamide
60 h; Ambient temperature;
参考文献
Nuzzo, Ralph G.; Haynie, Sharon L.; Wilson, Michael E.; Whitesides, George M.
Journal of Organic Chemistry, 1981 , vol. 46, # 14 p. 2861 - 2867
反应条件
1: (i) aq. AcOH, H2, Pd, MeOH, (ii) /BRN= 4720781/, Et3N, DMF
2: aq. CF3CO2H
View Scheme
参考文献
Hofmann,K. et al.
Journal of the American Chemical Society, 1978 , vol. 100, # 11 p. 3585 - 3590
