4-三氟甲氧基苯基异氰酸酯合成路线 （共 5 条）
反应条件
in tetrahydrofuran 0.75 h; Reflux;
参考文献
WO2011/48032 A1, ;
Page/Page column 64-65 ;
WO 2011/048032 A1
反应条件
in 1,4-dioxane T=80°C; 24 h;
参考文献
Chinese Chemical Letters, , vol. 24, # 5 p. 386 - 388
反应条件
in N,N-dimethyl-formamide T=20°C; 5 h;
参考文献
Blaser, Adrian; Palmer, Brian D.; Sutherland, Hamish S.; Kmentova, Iveta; Franzblau, Scott G.; Wan, Baojie; Wang, Yuehong; Ma, Zhenkun; Thompson, Andrew M.; Denny, William A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 312 - 326
反应条件
1: in tetrahydrofuran T=0 - 20°C; 2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 38 ;
US 20050054626 A1
反应条件
in N,N-dimethyl-formamide
T=23°C; 120 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2006/293336 A1, 2006 ;
Location in patent: Page/Page column 42 ;
US 20060293336 A1
