5,6,7,8-四氢喹唑啉-2,4(1H,3H)-二酮合成路线 （共 23 条）
反应条件
1: T=175 - 185°C; 2: With sodium hydroxide in water T=70°C; pH=13 - 14; 2 h;
参考文献
IMPACT THERAPEUTICS, INC.; CAI, Suixiong; TIAN, Ye Edward; WU, Lizhen; LIU, Lijun; WANG, Xiaozhu; JIANG, Yangzhen; WANG, Guoxiang; ZHANG, Xiuyan; XU, Qingbing; MENG, Zheng
Patent: WO2013/64083 A1, 2013 ;
Location in patent: Page/Page column 23; 24 ;
反应条件
ozone in water; acetic acid T=25°C; 1 h;
参考文献
Claudia, Crestini; Mincione, Enrico; Saladino, Raffaele; Nicoletti, Rosario
Tetrahedron, 1994 , vol. 50, # 10 p. 3259 - 3272
反应条件
hydrogenchloride in ethanol Heating / reflux;
参考文献
US2008/306053 A1, ;
Page/Page column 66 ;
反应条件
ozone in acetic acid T=25°C; 0.5 h;
参考文献
Tetrahedron Letters, , vol. 34, # 10 p. 1631 - 1634
反应条件
sulfuric acid in ethanol; water T=70°C; 48 h; pH=2; Yield given;
参考文献
Tetrahedron, , vol. 40, # 17 p. 3313 - 3320
反应条件
sodium hydroxide 1 h; Heating;
参考文献
Garcia Martinez, Antonio; Herrera Fernandez, Antonio; Moreno Jimenez, Florencio; Munoz Martinez, Pablo J.; Alonso Martin, Cristina; Subramanian, Laksminarayanapuran R.
Tetrahedron, 1996 , vol. 52, # 23 p. 7973 - 7982
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Bischoff, Christian; Schroeder, Edith
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 1 p. 129 - 132
反应条件
1: 85 percent / aq. sodium carbonate / 18 h / Ambient temperature 2: 71 percent / aq. HCl, acetic acid / 2 h / Heating View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 13, # 4 p. 891 - 901
反应条件
hydrogenchloride; acetic acid 2 h; Heating;
参考文献
Renault; Laduree; Robba
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 891 - 901
反应条件
1: 80 percent / MCPBA / CH2Cl2 / 2 h / Ambient temperature 2: 84 percent / 10percent aq. NaOH / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 23 p. 7973 - 7982
