6,6-二甲基-2-亚甲基-3-环己烯-1-羧酸乙酯合成路线 （共 9 条）
反应条件
n-butyllithium in diethyl ether; water
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5514821 A1, 1996 ;
反应条件
n-butyllithium in diethyl ether
参考文献
Yadav; Srinivas, Dale
Tetrahedron Letters, 1997 , vol. 38, # 44 p. 7789 - 7792
反应条件
n-butyllithium in diethyl ether; hexane 1.) 0 deg C, 60 min, 2.) r.t., 60 min;
参考文献
Bennani; Boehm
Journal of Organic Chemistry, 1995 , vol. 60, # 5 p. 1195 - 1200
反应条件
(i) Ph3P (ii) nBuLi, Et2O, hexane (iii) /BRN= 1704372/, Et2O; Multistep reaction;
参考文献
Buechi,G.; Wuest,H.
Helvetica Chimica Acta, 1971 , vol. 54, p. 1767 - 1775
反应条件
1: (i) Li, biphenyl, Et2O, THF, (ii) /BRN= 1947745/ 2: TsOH / benzene / Heating View Scheme
参考文献
Buechi,G.; Wuest,H.
Helvetica Chimica Acta, 1971 , vol. 54, p. 1767 - 1775
反应条件
1: (i) Li, biphenyl, Et2O, THF, (ii) /BRN= 1947745/ 2: TsOH / benzene / Heating 3: H2 / Lindlar catalyst / ethyl acetate View Scheme
参考文献
Buechi,G.; Wuest,H.
Helvetica Chimica Acta, 1971 , vol. 54, p. 1767 - 1775
反应条件
toluene-4-sulfonic acid in benzene Heating;
参考文献
Hoffmann-La Roche Inc.
Patent: US3962311 A1, 1976 ;
反应条件
toluene-4-sulfonic acid in benzene Heating;
参考文献
Buechi,G.; Wuest,H.
Helvetica Chimica Acta, 1971 , vol. 54, p. 1767 - 1775
反应条件
1: (i) O2, rose bengal, EtOH, (UV-irradiation), (ii) H2, PtO2
2: TsOH / toluene / Heating
3: LiAlH4 / tetrahydrofuran
4: (i) Py*HClCrO3, CH2Cl2, (ii) /BRN= 635680/, aq. KOH
View Scheme
参考文献
Kaiser; Lamparsky
Helvetica Chimica Acta, 1978 , vol. 61, # 1 p. 373 - 382
