1: With chloro-trimethyl-silane in diethyl ether T=20°C; 1 h; 2: With 1,1-dimethylethylmagnesium chloride in diethyl ether T=20°C; 3 h; Further stages.;

1.1: trimethylsilyl chloride / diethyl ether / 1 h / 20 °C 1.2: 62 percent / tert-butylmagnesium chloride / diethyl ether / 3 h / 20 °C 2.1: 87 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506104', constants.ctx, '0')">ethyl acetate</a> <br />20&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 96 percent / triethylamine / tetrahydrofuran<br />2: 2.58 g / H₂ / Pd/C / ethyl acetate / 20 h<br /> <br /> &nbsp;