4-(3-溴苯基)-丁烷-2-酮合成路线 （共 6 条）
反应条件
potassium carbonate in ethanol T=20°C; Reflux;
参考文献
Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center; Jones, Philip; DiFrancesco, Maria Emilia; Petrocchi, Alessia; Marszalek, Joe; Liu, Gang
Patent: US2014/57914 A1, 2014 ;
Location in patent: Paragraph 0375-0376 ;
反应条件
potassium carbonate in ethanol 18 h; Heating;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/114771 A1, 2007 ;
Location in patent: Page/Page column 25 ;
WO 2007/114771 A1
反应条件
in tetrahydrofuran T=-78 - 0°C;
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS LTD
Patent: WO2007/58601 A1, 2007 ;
Location in patent: Page/Page column 80 ;
WO 2007/058601 A1
反应条件
sodium hydroxide; sodium ethanolate 1)a) EtOH b) 1,5h, reflux 2) 4h, reflux; Yield given. Multistep reaction;
参考文献
Zimmerman, Howard E.; Swafford, Richard L.
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3069 - 3083
反应条件
n-butyllithium 1) THF 2) THF, 5h; Yield given. Multistep reaction;
参考文献
Zimmerman, Howard E.; Swafford, Richard L.
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3069 - 3083
反应条件
1: 1) n-butyllithium / 1) THF 2) THF, 5h 2: 0.90 g / CuCN / various solvent(s) / 5 h / 175 - 185 °C View Scheme
参考文献
Zimmerman, Howard E.; Swafford, Richard L.
Journal of Organic Chemistry, 1984 , vol. 49, # 17 p. 3069 - 3083
