hydrogenchloride in methanol 1 h; Ambient temperature;

1: 68 percent / 2 M HCl / methanol / 1 h / Ambient temperature 2: 88 percent / pyridine / tetrahydrofuran / 0.5 h / 0 °C 3: 81 percent / 1 h / 100 °C 4: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) from 0 deg C to room temp., 1 h View Scheme

1: 68 percent / 2 M HCl / methanol / 1 h / Ambient temperature 2: 88 percent / pyridine / tetrahydrofuran / 0.5 h / 0 °C 3: 81 percent / 1 h / 100 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11405916', constants.ctx, '0')">copper(l) iodide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />T=-78&deg;C;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11405916', constants.ctx, '0')">copper(l) iodide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=-78&deg;C;&nbsp;Addition;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: toluene-4-sulfonic acid / dichloromethane / 1 h / 0 &deg;C<br />2: benzoic acid / toluene / 72 h / 20 &deg;C<br /> <br /> &nbsp;