4-(4-氨基苯甲酰基)四氢-1(2H)-吡嗪羧酸叔丁酯合成路线 （共 3 条）
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 18 h;
参考文献
CATABASIS PHARMACEUTICALS, INC.; MILNE, Jill C.; JIROUSEK, Michael R.; VU, Chi B.
Patent: WO2013/177536 A2, 2013 ;
Location in patent: Paragraph 0260 ;
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; butan-1-ol in DMF (N,N-dimethyl-formamide) T=20°C; 22 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2004/46120 A2, 2004 ;
Location in patent: Page 179 ;
WO 2004/046120 A2
反应条件
1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 0 - 20 °C 2: palladium 10 on activated carbon; hydrogen / methanol / 18 h / 20 °C / 760.05 Torr View Scheme
