1: 98 percent / EDCI; HOBt; Et3N / CHCl3; dimethylformamide / 16 h / 20 °C 2: aq. HCl / methanol / 16 h / 60 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: aq. HCl / methanol / 16 h / 60 &deg;C<br />2: 64 percent / pyridine / diethyl ether<br />3: 51 percent / Et₃N / tetrahydrofuran; H₂O / 20 &deg;C<br /> <br /> &nbsp;