2-异丙基-2-苯基乙酸合成路线 （共 18 条）
反应条件
1: phenylacetic acid With 1,2-disodiostilbene in tetrahydrofuran T=0°C; 2 h; Inert atmosphere; 2: 2-iodo-propane in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 3: With hydrogenchloride in water regioselective reaction;
参考文献
Azzena, Ugo; Dettori, Giovanna; Pisano, Luisa; Pittalis, Mario
Tetrahedron, 2011 , vol. 67, # 19 p. 3470 - 3475
反应条件
sodium hydroxide in methanol; water
参考文献
Hoffmann-La Roche Inc.
Patent: US5250517 A1, 1993 ;
US 5250517 A
反应条件
1: phenylacetic acid With lithium diisopropyl amide in tetrahydrofuran; ethylbenzene; toluene T=20°C; 1 h; Inert atmosphere; 2: isopropyl bromide in tetrahydrofuran; ethylbenzene; toluene T=20°C; Inert atmosphere; 3: With hydrogenchloride in water
参考文献
Kulig; Ignasik; Malawska
Polish Journal of Chemistry, 2009 , vol. 83, # 9 p. 1629 - 1636
反应条件
sulfuric acid 15 h; Heating;
参考文献
Knorr, Rudolf; Lattke, Ernst
Chemische Berichte, 1981 , vol. 114, # 6 p. 2116 - 2131
反应条件
sulfuric acid THF, -20 deg C, 10 min; THF, water, 0 deg C, 30 min;
参考文献
Yao, Ching-Fa; Chen, Wen-Chang; Lin, Yu-Mei
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6339 - 6342
反应条件
sodium ethanolate Erhitzen des entstandenen Estergemisches mit Kalilauge und Destillieren der durch Ansaeuern mit Schwefelsaeure in Freiheit gesetzten Saeure;
参考文献
Journal of the American Chemical Society, , vol. 51, p. 2545
反应条件
1: 30percent aq. potassium hydroxide, (tributyl)-benzylammonium iodide (TBBAI) / toluene / 10 h 2: aq. sulphuric acid / 4 h / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, , vol. 29, # 11 p. 1034 - 1040
反应条件
H2O in water; acetonitrile T=25°C; var. pH and μ; Rate constant;
参考文献
Journal of Organic Chemistry, , vol. 54, # 12 p. 2843 - 2848
反应条件
in toluene T=25°C; 16 h; Yield given. Yields of byproduct given;
参考文献
Angewandte Chemie, , vol. 96, # 2 p. 166 - 167
反应条件
Yield givenMultistep reaction;
参考文献
Chemical Communications, , # 2 p. 187 - 188
