sodium carbonate; zinc in water T=30°C;

palladium on activated charcoal; water-d2 T=200°C; 2 h;

1.1: 2 h / 20 °C 2.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C 2.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C 3.1: 76 percent / aq. NaOH / methanol / 1.75 h / 20 °C 4.1: 35 percent / glacial acetic acid; dimethylaminoborane / 0.33 h / 60 °C 5.1: 80 percent / aq. NaOH / 6 h / 20 °C View Scheme

T=20°C; 2 h;

1.1: 2 h / 20 °C 2.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / tetrahydrofuran / 0.5 h / 20 °C 2.2: diisopropylethylamine / tetrahydrofuran / 4 h / 20 °C View Scheme