4’-溴-3’-氟乙酰苯胺合成路线 （共 6 条）
反应条件
N-bromosuccinmide in dichloromethane a) reflux, 5 h, b) room temp., 16 h;
参考文献
Gray, G. W.; Hird, M.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1991 , vol. 204, p. 43 - 64
参考文献
The Secretary of State for Defence in her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
Patent: US5888421 A1, 1999 ;
反应条件
1: 70 percent / acetic acid / 0.33 h / Heating 2: 100 percent / NBS / CH2Cl2 / a) reflux, 5 h, b) room temp., 16 h View Scheme
参考文献
Molecular Crystals and Liquid Crystals (1969-1991), , vol. 204, p. 43 - 64
反应条件
hydrogenchloride in ethanol 2 h; Heating;
参考文献
Gray, G. W.; Hird, M.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1991 , vol. 204, p. 43 - 64
反应条件
1: 99 percent / 36percent HCl / ethanol / 2 h / Heating 2: 1) 36percent HCl, NaNO2, 2) KI / 1) H2O, 0 deg C, 20 min, 2) H2O, cyclohexane, room temp., 16 h View Scheme
参考文献
Gray, G. W.; Hird, M.; Toyne, K. J.
Molecular Crystals and Liquid Crystals (1969-1991), 1991 , vol. 204, p. 43 - 64
反应条件
1: With sulfuric acid; potassium nitrate T=20°C; 2: With hydrogenchloride in tetrahydrofuran; water T=120°C; 0.333333 h; Microwave irradiation; 3: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne
Patent: WO2010/52448 A2, 2010 ;
Location in patent: Page/Page column 40-41 ;
WO 2010/052448 A2
