3-(3-氟苯基)丙烯酸乙酯合成路线 （共 10 条）
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 18 h;
参考文献
Fabio, Karine; Guillon, Christophe; Lacey, Carl J.; Lu, Shi-Fang; Heindel, Ned D.; Ferris, Craig F.; Placzek, Michael; Jones, Graham; Brownstein, Michael J.; Simon, Neal G.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 3 p. 1337 - 1345
反应条件
potassium phosphate; dipalladium(II)(1,1'-di-t-butyl-3,3'-(1,2-ethanediyl)bisimidazolium)dipyridinetetradichloride in N,N-dimethyl acetamide T=110°C; Heck Reaction; 5 h; Inert atmosphere;
参考文献
Li, Yunfei; Liu, Gang; Cao, Changsheng; Wang, Shuzhan; Li, Yuling; Pang, Guangsheng; Shi, Yanhui
Tetrahedron, 2013 , vol. 69, # 30 p. 6241 - 6250
反应条件
sodium 2-[2-(pyridin-3-yl)ethylamino]ethansulfonate; palladium diacetate in water T=20°C; Heck reaction; 3.5 h;
参考文献
Pawar, Shivaji S.; Dekhane, Deepak V.; Shingare, Murlidhar S.; Thore, Shivaji N.
Tetrahedron Letters, 2008 , vol. 49, # 27 p. 4252 - 4255
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran T=0°C; Horner-Wadsworth-Emmons olefination; 0.75 h; 2: 3-fluorobenzenecarboxaldehyde in tetrahydrofuran T=0 - 20°C; Horner-Wadsworth-Emmons olefination;
参考文献
Fan, Xing; Zhang, Hu-Shan; Chen, Li; Long, Ya-Qiu
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2827 - 2840
参考文献
Glaxo Wellcome Inc.
Patent: US5872118 A1, 1999 ;
反应条件
copper diacetate; palladium diacetate; 1,10-phenanthrolin-2-ol T=120°C; Heck Reaction; 15 h; Overall yield = 79 percent; regioselective reaction;
参考文献
Ying, Cheng-Hao; Yan, Shao-Bai; Duan, Wei-Liang
Organic Letters, 2014 , vol. 16, # 2 p. 500 - 503
反应条件
1: With potassium carbonate Horner-Wadsworth-Emmons olefination; 6 h; Neat (no solvent)high-speed ball milling; 2: With Oxonereg; 12 h; Neat (no solvent)high-speed ball milling; optical yield given as percent dediastereoselective reaction;
参考文献
Shearouse, William C.; Korte, Chelsea M.; Mack, James
Green Chemistry, 2011 , vol. 13, # 3 p. 598 - 601
反应条件
hydrogenchloride; ethanol
参考文献
Kindler
Chemische Berichte, 1936 , vol. 69, p. 2799
反应条件
1: Diazotization 2: hydrogen chloride; ethanol View Scheme
参考文献
Kindler
Chemische Berichte, 1936 , vol. 69, p. 2799
反应条件
1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C 2: dipyridinium dichromate / dichloromethane / 20 °C / Inert atmosphere View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 20, # 3 p. 1337 - 1345
