3-氟-4-甲氧基苯甲醛合成路线 （共 31 条）
反应条件
Behandlung des Reaktionsprodukts mit kalter wss. SO2-Loesung;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 135, p. 101,113
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=-78°C; 1.75 h; 2: With methanol in tetrahydrofuran 0.5 h; Heating / reflux;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 90-91 ;
反应条件
potassium tert-butylate in tetrahydrofuran; methanol; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: Ag2O; H2O 2: HCl; pyridine View Scheme
参考文献
Lock
Monatshefte fuer Chemie, 1955 , vol. 86, p. 511,515
反应条件
water; silver(l) oxide
参考文献
Lock
Monatshefte fuer Chemie, 1955 , vol. 86, p. 511,515
参考文献
DAINIPPON SUMITOMO PHARMA CO., LTD.
Patent: US2012/225876 A1, 2012 ;
反应条件
sodium borohydride in methanol; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1223170 A1, 2002 ;
反应条件
1: in tetrahydrofuran T=-78 - 20°C; 2: With oxalyl dichloride; dimethyl sulfoxide in tetrahydrofuran; dichloromethane T=-78°C; Inert atmosphere; 3: With triethylamine in tetrahydrofuran; dichloromethane
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: EP2168959 A1, 2010 ;
Location in patent: Page/Page column 165 ;
反应条件
1.1: tetrahydrofuran / 5 h / -78 - 20 °C / |Inert atmosphere 1.2: |Inert atmosphere 2.1: phosgene; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C 2.2: 2 h / -78 - 20 °C View Scheme
参考文献
Ochiai, Koji; Takita, Satoshi; Kojima, Akihiko; Eiraku, Tomohiko; Iwase, Kazuhiko; Kishi, Tetsuya; Ohinata, Akira; Yageta, Yuichi; Yasue, Tokutaro; Adams, David R.; Kohno, Yasushi
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 375 - 381
反应条件
sulfuric acid; nitric acid T=-10°C;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/99196 A1, 2004 ;
Location in patent: Page 8 ;
