2,3,4,6-四氟吡啶合成路线 （共 13 条）
反应条件
ammonium formate; palladium on activated charcoal in octanol T=25°C; 6 h;
参考文献
Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
反应条件
water; copper; zinc in N,N-dimethyl-formamide T=70°C; 8 h; Title compound not separated from byproducts;
参考文献
Russian Journal of Organic Chemistry, , vol. 29, # 5.2 p. 895 - 896
Zhurnal Organicheskoi Khimii, , vol. 29, # 5 p. 1078 - 1079
反应条件
potassium tetrafluorocobaltate in gaseous matrix T=215 - 225°C; 1.) 3.5-4 h; 2.) 2 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 21, p. 171 - 190
反应条件
catalyst: Pd on active carbon in not given Hydrogenation in presence of catalyst (10 percent Pd/90 percent active carbon) at 250 °C.;
参考文献
Journal of the Chemical Society, , p. 5045 - 5048
GB1134651 , ;
C.A., , vol. 70, p. 57661
反应条件
zinc in water; N,N-dimethyl-formamide 20 h; Heating;
参考文献
Russian Journal of Organic Chemistry, , vol. 36, # 10 p. 1488 - 1499
反应条件
in diethyl ether 122 h; Irradiation;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2520 - 2522
反应条件
1: 90 percent / hydrazine monohydrate / ethanol / 2 h / 50 °C 2: 73 percent / aq. CuSO4 / 0.75 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 11, # 6 p. 1903 - 1910
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-75°C; 0.75 h;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: n-butyllithium; 2,3,4,6-Tetrafluoropyridine in diethyl ether; hexane T=-70°C; Metallation; Alkylation; 0.666667 h; 2: chloro-trimethyl-silane T=-70 - 20°C; Alkylation; Silylation; 2.5 h;
参考文献
Coe, Paul L.; Rees, Anthony J.
Journal of Fluorine Chemistry, 2000 , vol. 101, # 1 p. 45 - 60
反应条件
1: 2,3,4,6-Tetrafluoropyridine; lithium diisopropyl amide in diethyl ether T=-78°C; Substitution; Metallation; 0.666667 h; 2: chloro-trimethyl-silane in diethyl ether T=-70 - 20°C; Silylation; 4.5 h;
参考文献
Coe, Paul L.; Rees, Anthony J.
Journal of Fluorine Chemistry, 2000 , vol. 101, # 1 p. 45 - 60
