2,3,4,5-四氟吡啶合成路线 （共 17 条）
反应条件
potassium fluoride; anhydrous tetramethylammonium chloride in dimethyl sulfoxide T=150°C; 2 h;
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
catalyst: Pd on active carbon in gaseous matrix C5F5N is passed in H2 stream over catalyst (10 percent Pd/90 percent active carbon) at 320 °C.;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
triethylsilane; [Rh(μ-H)(1,3-bis(diisopropylphosphanyl)propane)]2 in benzene-d6 T=50°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Zamostna, Lada; Ahrens, Mike; Braun, Thomas
Journal of Fluorine Chemistry, 2013 , vol. 155, p. 132 - 142
反应条件
in benzene-d6 T=50°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Zamostna, Lada; Ahrens, Mike; Braun, Thomas
Journal of Fluorine Chemistry, 2013 , vol. 155, p. 132 - 142
反应条件
caesium tetrafluorocobaltate(III) in gaseous matrix T=395 - 405°C; 0.5 h; Further byproducts given;
参考文献
Plevey, Raymond G.; Rendell, Richard W.; Tatlow, John Colin
Journal of Fluorine Chemistry, 1982 , vol. 21, p. 159 - 170
反应条件
1.1: 65 percent / aq. CuSO4 / Heating 2.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 78 percent / Br2 / 1 h / -75 °C 3.1: 70 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 2.1: 65 percent / aq. CuSO4 / Heating 3.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 3.2: 78 percent / Br2 / 1 h / -75 °C 4.1: 70 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: 90 percent / Zn; aq. ammonia / 6 h / 0 °C 2.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating 3.1: 65 percent / aq. CuSO4 / Heating 4.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 4.2: 78 percent / Br2 / 1 h / -75 °C 5.1: 70 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 78 percent / Br2 / 1 h / -75 °C 2.1: 70 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
t-Bu-XantPhos; tBuXantphosAu(AuCl2); (Ph)2SiH2; acetic acid in 1,2-dichloro-ethane T=80°C; 24 h; Inert atmosphere;
参考文献
Zhan, Jin-Hui; Lv, Hongbin; Yu, Yi; Zhang, Jun-Long
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1529 - 1541
