hydrogenchloride; sodium borohydride in methanol; CeCl3; water; acetonitrile

1: 1) Hg(II) trifluoroacetate, N(C2H5)3, 2) NaBH4, NaOMe / 1) THF, -78 deg C, 1 h, 2) THF - MeOH, -78 deg C, 1 h 2: 74 percent / tetrabutylammoniumfluoride / tetrahydrofuran / 15 h / 15 °C 3: alkaline hydrolysis View Scheme

1: 74 percent / tetrabutylammoniumfluoride / tetrahydrofuran / 15 h / 15 °C 2: alkaline hydrolysis View Scheme

alkaline hydrolysis;

phosphate buffer (pH=ca. 7); water T=10 - 30°C; activation parameters: ΔS(excit.), ΔG(excit.), E investigated; depends on cyclodextrin and phosphate buffer concentration, pH, solvent and temperature; KineticsThermodynamic data;