1-甲酰氨基-3,5-二甲基金刚烷合成路线 （共 9 条）
反应条件
1: 1,3-dimethyladamantane With sulfuric acid; nitric acid T=0 - 5°C; 2: formamide T=55 - 60°C; 2 h; 3: With ammonia in dichloromethane; water T=0 - 25°C;
参考文献
Merz Pharma GmbH and Co. KGaA
Patent: EP2103597 A1, 2009 ;
Location in patent: Page/Page column 6 ;
反应条件
T=22 - 75°C; Inert atmosphere; Product distribution / selectivity;
参考文献
WO2010/15415 A1, ;
Page/Page column 16-17 ;
反应条件
1: T=157°C; 14 h; 2: With water in dichloromethane T=5 - 25°C; Product distribution / selectivity;
参考文献
WO2006/122238 A1, ;
Page/Page column 11-12 ;
反应条件
formamide T=155°C; 8 h; Product distribution / selectivity;
参考文献
WO2006/122238 A1, ;
Page/Page column 14-15 ;
反应条件
1: bromine; water / 25 °C / |Reflux 2: hydrogenchloride / water / 15 h / 25 - 30 °C 3: 8 h / 150 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 2 p. 268 - 269
反应条件
1: hydrogenchloride / water / 15 h / 25 - 30 °C 2: 8 h / 150 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 11, # 2 p. 268 - 269
参考文献
Reddy, Jambula Mukunda; Prasad, Ganji; Raju, Veeramalla; Ravikumar, Mylavarapu; Himabindu, Vurumidi; Reddy, Ghanta Mahesh
Organic Process Research and Development, 2007 , vol. 11, # 2 p. 268 - 269
反应条件
1: With water; sodium hydroxide in methanol 12 h; Reflux; 2: With hydrogenchloride in methanol; n-heptane T=60 - 65°C; Product distribution / selectivity;
参考文献
MERZ PHARMA GMBH andamp; CO. KGAA; GOLD, Markus-Rene; JIRGENSONS, Aigars; HUBER, Florian, Anton, Martin
Patent: WO2010/69555 A1, 2010 ;
Location in patent: Page/Page column 22-23 ;
反应条件
sodium hydroxide; butan-1-ol 1 h; Reflux; Product distribution / selectivity;
参考文献
MERZ PHARMA GMBH andamp; CO. KGAA; GOLD, Markus-Rene; JIRGENSONS, Aigars; HUBER, Florian, Anton, Martin
Patent: WO2010/69555 A1, 2010 ;
Location in patent: Page/Page column 19-21 ;
