2-苄基-八氢-吡咯3,4-C吡啶合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=50°C; 2 h;
参考文献
Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; Mortell, Kathleen H.; Nersesian, Diana L.; Schrimpf, Michael R.
Patent: US2005/101602 A1, 2005 ;
Location in patent: Page/Page column 35 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 6 h; RefluxInert atmosphere;
参考文献
WO2013/71697 A1, ;
Paragraph 00334 ;
反应条件
1: hydrogen; palladium 10 on activated carbon / 2-methoxy-ethanol / 6 h / 35 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / |Reflux; |Inert atmosphere View Scheme
反应条件
1: N-ethyl-N,N-diisopropylamine / acetone / 5 h / |Reflux 2: hydrogen; palladium 10 on activated carbon / 2-methoxy-ethanol / 6 h / 35 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / |Reflux; |Inert atmosphere View Scheme
反应条件
1: N-ethyl-N,N-diisopropylamine / acetone / 5 h / |Reflux 2: hydrogen; palladium 10 on activated carbon / 2-methoxy-ethanol / 6 h / 35 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / |Reflux; |Inert atmosphere View Scheme
反应条件
1: sodium carbonate / tetrahydrofuran / 0 - 20 °C 2: palladium hydroxide on carbon; hydrogen / ethyl acetate / 3 h / 20 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu
Patent: WO2013/71697 A1, 2013 ;
