(R)-1-Boc-2-哌啶乙酸合成路线 （共 11 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in methanol; water; acetonitrile T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Tetrahedron, , vol. 67, # 38 p. 7412 - 7417
反应条件
sodium hydroxide in water; tert-butyl alcohol T=2°C;
参考文献
US2003/220368 A1, ;
Page/Page column 29 ;
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: 69 percent / AcCl / toluene / Heating 2.1: Vitride / toluene / -78 °C 2.2: 60 percent / HCl 3.1: TiCl4 / toluene / 50 °C 4.1: K2CO3 / acetone 5.1: OsO4; NaIO4 / dioxane; H2O 6.1: LiAlH4 / diethyl ether / Heating 6.2: 52 percent / H2 / Pd-C / methanol 7.1: NaOH / dioxane; H2O 8.1: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1: NaOH / dioxane; H2O 2: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: TiCl4 / toluene / 50 °C 2.1: K2CO3 / acetone 3.1: OsO4; NaIO4 / dioxane; H2O 4.1: LiAlH4 / diethyl ether / Heating 4.2: 52 percent / H2 / Pd-C / methanol 5.1: NaOH / dioxane; H2O 6.1: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: Vitride / toluene / -78 °C 1.2: 60 percent / HCl 2.1: TiCl4 / toluene / 50 °C 3.1: K2CO3 / acetone 4.1: OsO4; NaIO4 / dioxane; H2O 5.1: LiAlH4 / diethyl ether / Heating 5.2: 52 percent / H2 / Pd-C / methanol 6.1: NaOH / dioxane; H2O 7.1: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: LiAlH4 / diethyl ether / Heating 1.2: 52 percent / H2 / Pd-C / methanol 2.1: NaOH / dioxane; H2O 3.1: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1.1: K2CO3 / acetone 2.1: OsO4; NaIO4 / dioxane; H2O 3.1: LiAlH4 / diethyl ether / Heating 3.2: 52 percent / H2 / Pd-C / methanol 4.1: NaOH / dioxane; H2O 5.1: PDC / dimethylformamide View Scheme
参考文献
Organic letters, , vol. 3, # 2 p. 193 - 196
反应条件
1: (S)-[α,α-bis(3,5-bistrifluoromethyl)phenyl]-2-pyrrolidine methanol trimethylsilyl ether; benzoic acid / chloroform / 22 h / -50 °C / Inert atmosphere 2: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / methanol; water; acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron, , vol. 67, # 38 p. 7412 - 7417
