1H-吡咯并[2,3-b]吡啶-4-羧酸甲酯合成路线 （共 5 条）
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) T=60°C; 12 h;
参考文献
Allegretti, Marcello; Arcadi, Antonio; Marinelli, Fabio; Nicolini, Luca
Synlett, 2001 , # 5 p. 609 - 612
反应条件
in methanol; hexane; dichloromethane T=20°C; 0.5 h; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 10 p. 3039 - 3053
反应条件
hydrazine in methanol; water T=80°C; 4 h; Heating / reflux;
参考文献
WO2009/71577 A1, ;
Page/Page column 50 ;
WO 2009/071577 A1
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 1.08 h / -5 °C / Inert atmosphere 2.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 25 - 80 °C 3.1: water; lithium hydroxide hydrate / methanol / 2.5 h / 20 °C 3.2: 0.5 h View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/184015 A1, 2011 ;
反应条件
1: 3-chloro-benzenecarboperoxoic acid / ethylene glycol dimethyl ether / 22.5 h / 20 °C / Inert atmosphere 2: chloroformic acid ethyl ester; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran / 16 h / 50 °C / Inert atmosphere View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/184015 A1, 2011 ;
