4,6-二甲基-2-甲磺酰基嘧啶合成路线 （共 10 条）
反应条件
water; chlorine in dichloromethane T=0°C;
参考文献
Abbott GmbH and Co., KG
Patent: US6670367 B1, 2003 ;
Location in patent: Page column 15-16 ;
反应条件
1: aq. NaOH 2: 54.2 g / peracetic acid / CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 11 p. 2776 - 2795
反应条件
in ethanol 1.) ice bath, 2.) room temperature;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
in methanol; acetonitrile
参考文献
NIHON BAYER AGROCHEM K.K.
Patent: EP571856 A1, 1993 ;
反应条件
lithium hydride in N,N-dimethyl-formamide T=30 - 32°C; 48 h;
参考文献
Sata, Kaushik Babubhai; Pandey, Bipin
Patent: US2012/184573 A1, 2012 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
1: (S)-1-(2,4-dichlorophenyl)ethylammonium (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionate With lithium amide in N,N-dimethyl-formamide 2: 2-methylsulphonyl-4,6-dimethyl-pyrimidine in N,N-dimethyl-formamide 3: Acidic conditions;
参考文献
CADILA HEALTHCARE LIMITED; SATA, Kaushik, Babubhai; PANDEY, Bipin
Patent: WO2011/4402 A2, 2011 ;
Location in patent: Page/Page column 23 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Jin, Chuanfei; Liang, Yong-Ju; He, Hongwu; Fu, Liwu
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 1 p. 429 - 432
参考文献
Shell Research Limited
Patent: US5462944 A1, 1995 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=90 - 92°C; 1 h; Inert atmosphere;
参考文献
CIPLA LIMITED; KING, Lawrence; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; NAIK, Sanjay; GHAGARE, Maruti; CHIKHALIKAR, Sandip Vasant
Patent: WO2013/57468 A1, 2013 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 15 h / 20 - 90 °C
2.1: water; sodium hydroxide / 1,4-dioxane / 20 - 90 °C
2.2: pH Ca. 1
3.1: tetrahydrofuran; methanol; hexane / 0.5 h / 20 °C
View Scheme
参考文献
Peng, Xianyou; Li, Peijun; Shi, Yian
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 701 - 703
