(2-(苄氧基)-4-氟苯基)甲醇合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in ethanol T=0°C; 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; SHIONOGI and CO. LTD; KAWASUJI, Takashi
Patent: WO2007/19098 A2, 2007 ;
Location in patent: Page/Page column 43 ;
反应条件
sulfuric acid in tetrahydrofuran; diethyl ether
参考文献
Tsuji, Kiyoshi; Terasaka, Tadashi; Nakamura, Katsuya
Patent: US2004/97571 A1, 2004 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 48 h; Inert atmosphere; 2: With sodium hydroxide in tetrahydrofuran Inert atmosphere;
参考文献
ACADIA PHARMACEUTICALS, INC.; SCHLIENGER, Nathalie; THYGESEN, Mikkel; ULDAM, Henriette, Kold; SCHMELZER, Kara; TABATABAEI, Ali
Patent: WO2010/111353 A1, 2010 ;
Location in patent: Page/Page column 64-65 ;
WO 2010/111353 A1
反应条件
1: With oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-76°C; Swern Oxidation; 1.5 h; 2: With triethylamine in dichloromethane T=20°C;
参考文献
ACADIA PHARMACEUTICALS, INC.; SCHLIENGER, Nathalie; THYGESEN, Mikkel; ULDAM, Henriette, Kold; SCHMELZER, Kara; TABATABAEI, Ali
Patent: WO2010/111353 A1, 2010 ;
Location in patent: Page/Page column 64-65 ;
WO 2010/111353 A1
参考文献
Tsuji, Kiyoshi; Terasaka, Tadashi; Nakamura, Katsuya
Patent: US2004/97571 A1, 2004 ;
