N-甲氧基-n-甲基-1H-吲唑-3-羧酰胺合成路线 （共 13 条）
反应条件
pyridine; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in tetrahydrofuran T=0 - 20°C; 13.5 h;
参考文献
Crestey, Francois; Stiebing, Silvia; Legay, Remi; Collot, Valerie; Rault, Sylvain
Tetrahedron, 2007 , vol. 63, # 2 p. 419 - 428
反应条件
hydrogenchloride; 1,1'-carbonyldiimidazole in dichloromethane; N,N-dimethyl-formamide
参考文献
EPITHERIX, LLC
Patent: US2011/34441 A1, 2011 ;
反应条件
triethylamine T=20°C; 6 h;
参考文献
Bhatt, Aaditya; Gurukumar; Basu, Amartya; Patel, Maulik R.; Kaushik-Basu, Neerja; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5138 - 5145
反应条件
1: 3,5-difluoroanisole With n-butyllithium in tetrahydrofuran; hexane T=-84°C; 1 h; 2: tert-butyl 3-{[methoxy(methyl)amino]carbonyl}-1H-indazole-1-carboxylate in tetrahydrofuran; hexane T=-84 - 20°C;
参考文献
Crestey, Francois; Stiebing, Silvia; Legay, Remi; Collot, Valerie; Rault, Sylvain
Tetrahedron, 2007 , vol. 63, # 2 p. 419 - 428
反应条件
pyridine; 1,2-dichloro-ethane in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
Lukasik, Pawel M.; Elabar, Sherifa; Lam, Frankie; Shao, Hao; Liu, Xiangrui; Abbas, Abdullah Y.; Wang, Shudong
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 311 - 322
反应条件
1: 4-methyl-morpholine / tetrahydrofuran / 4 h / -20 °C / Inert atmosphere 2: triethylamine / 6 h / 20 °C View Scheme
参考文献
Bhatt, Aaditya; Gurukumar; Basu, Amartya; Patel, Maulik R.; Kaushik-Basu, Neerja; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5138 - 5145
反应条件
in tetrahydrofuran T=-84 - 20°C;
参考文献
Crestey, Francois; Stiebing, Silvia; Legay, Remi; Collot, Valerie; Rault, Sylvain
Tetrahedron, 2007 , vol. 63, # 2 p. 419 - 428
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-15 - 20°C; 13 h;
参考文献
Tetrahedron Letters, , vol. 48, # 14 p. 2457 - 2460
Tetrahedron, , vol. 63, # 2 p. 419 - 428
反应条件
diisobutylaluminium hydride in tetrahydrofuran T=-84 - 20°C;
参考文献
Tetrahedron, , vol. 63, # 2 p. 419 - 428
反应条件
1: 76 percent / LiAlH4 / tetrahydrofuran / 13 h / -15 - 20 °C
2: 100 percent / triethylamine; dimethylaminopyridine / CH2Cl2 / 13 h / 0 - 20 °C
View Scheme
参考文献
Crestey, Francois; Collot, Valerie; Stiebing, Silvia; Lohier, Jean-Francois; Santos, Jana Sopkova-de Oliveira; Rault, Sylvain
Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2457 - 2460
