(E)-9-十二碳烯-1-醇乙酸酯合成路线 （共 50 条）
反应条件
hydrogenchloride; acetic anhydride; diisobutylaluminium hydride in tetrahydrofuran; n-heptane
参考文献
PHILLIPS PETROLEUM COMPANY
Patent: EP235742 B1, 1991 ;
反应条件
pyridine Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
GRUBBS, ROBERT H.; HERBERT, MYLES B.; WICKENS, ZACHARY K.; MARX, VANESSA M.
Patent: US2013/231499 A1, 2013 ;
Location in patent: Paragraph 0185; 0186 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=25°C; 0.5 h;
参考文献
Moiseenkov, Alexander M.; Czeskis, Boris A.; Ivanova, Natalya M.; Nefedov, Oleg M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2639 - 2649
反应条件
1: (E)-1-hex-3-enyl bromide With magnesium in tetrahydrofuran Metallation; 6 h; 2: With manganese (II) chloride in tetrahydrofuran Transmetallation; 12 h; 3: 1-acetoxy-6-bromohexane With lithium chloride; copper dichloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=0 - 5°C; Coupling reaction;
参考文献
Belmar, Julio; Tellez; Baeza; Freer
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2000 , vol. 55, # 7 p. 583 - 586
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.25 h 1.2: MnCl2 / tetrahydrofuran / 12 h / 20 °C 1.3: 70 percent / CuCl2; LiCl / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 6 h / 20 °C 2.1: 78 percent / TFA / methanol / 20 °C 3.1: 94 percent / pyridine; DMAP / 12 h / 20 °C View Scheme
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 7 p. 1372 - 1380
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 7 p. 1555 - 1562
反应条件
urea in methanol 16 h; Ambient temperature;
参考文献
Popovici, N.; Botar, A. A.; Barabas, A.; Oprean, I.; Hodosan, F.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 1 p. 17 - 26
反应条件
potassium iodide in acetic acid 16 h; Heating;
参考文献
Zakharkin, L. I.; Petrushkina, E. A.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, # 8 p. 1419 - 1422
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 8 p. 1623 - 1628
参考文献
Singh, Krishna Nand; Singh, Manorama; Misra, Ram Achal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 4 p. 431 - 434
反应条件
in pyridine; acetic acid T=0°C; 13 h;
参考文献
Vig; Kad; Sabharwal; Dogra; Sharma
Journal of the Indian Chemical Society, 1989 , vol. 66, # 4 p. 233 - 235
反应条件
1: 78 percent / TFA / methanol / 20 °C 2: 94 percent / pyridine; DMAP / 12 h / 20 °C View Scheme
参考文献
Canevet; Roeder; Vostrowsky; Bestmann
Chemische Berichte, 1980 , vol. 113, # 3 p. 1115 - 1120
