(E)-9-十二碳烯-1-醇乙酸酯合成路线 （共 50 条）
反应条件
1: 90 percent / HCl / 1) 0 deg C, 4h, 2) r.t., 24h 2: 97 percent / m-chloroperbenzoic acid, Na-acetate / CHCl3 / 3 h 3: 1) butyl lithium, diisopropylamine / 1) ether, 1h, 2) 6h, reflux 4: 95 percent / triethylamine / CH2Cl2 / 0.5 h / 0 °C 5: 1) CuI2 / 1) ether, -10 deg C, 10min, 2) 0 deg C, 4h 3) r.t. 6: 90 percent / PTS / methanol / 4 h 7: pyridine / Ambient temperature View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Verma, N. K.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 692 - 694
反应条件
1: LAH 2: 90 percent / HCl / 1) 0 deg C, 4h, 2) r.t., 24h 3: 97 percent / m-chloroperbenzoic acid, Na-acetate / CHCl3 / 3 h 4: 1) butyl lithium, diisopropylamine / 1) ether, 1h, 2) 6h, reflux 5: 95 percent / triethylamine / CH2Cl2 / 0.5 h / 0 °C 6: 1) CuI2 / 1) ether, -10 deg C, 10min, 2) 0 deg C, 4h 3) r.t. 7: 90 percent / PTS / methanol / 4 h 8: pyridine / Ambient temperature View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Verma, N. K.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 692 - 694
反应条件
1: 95 percent / triethylamine / CH2Cl2 / 0.5 h / 0 °C 2: 1) CuI2 / 1) ether, -10 deg C, 10min, 2) 0 deg C, 4h 3) r.t. 3: 90 percent / PTS / methanol / 4 h 4: pyridine / Ambient temperature View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Verma, N. K.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 692 - 694
反应条件
1: 1) CuI2 / 1) ether, -10 deg C, 10min, 2) 0 deg C, 4h 3) r.t. 2: 90 percent / PTS / methanol / 4 h 3: pyridine / Ambient temperature View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Verma, N. K.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 692 - 694
反应条件
1: 97 percent / m-chloroperbenzoic acid, Na-acetate / CHCl3 / 3 h 2: 1) butyl lithium, diisopropylamine / 1) ether, 1h, 2) 6h, reflux 3: 95 percent / triethylamine / CH2Cl2 / 0.5 h / 0 °C 4: 1) CuI2 / 1) ether, -10 deg C, 10min, 2) 0 deg C, 4h 3) r.t. 5: 90 percent / PTS / methanol / 4 h 6: pyridine / Ambient temperature View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Verma, N. K.; Malik, Neera
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 692 - 694
反应条件
in acetic acid T=50°C; 10 h; Yield given;
参考文献
Oprean, I.; Ciupe, Hilke; Gansca, Lucia; Hodosan, F.
Journal fuer Praktische Chemie (Leipzig), 1987 , vol. 329, # 2 p. 283 - 289
反应条件
1: 1.) CuI, 2,2'-bipyridyl, Mg, 2.) TsOH / 1.) THF, HF, 20 deg C, 2 h, 20 deg C, 16 h, reflux, 4 h, 2.) EtOH, rt, 24 h 2: 81 percent / Py / 48 h / Ambient temperature View Scheme
参考文献
Odinokov; Vakhidov; Shakhmaev; Zorin
Chemistry of Natural Compounds, 1996 , vol. 32, # 6 p. 912 - 914
反应条件
dilithium tetrachlorocuprate; iodine; magnesium 1) THF/diethyl ether, reflux, 2 h, 2) THF/diethyl ether; Yield given. Multistep reaction;
参考文献
Popovici, N.; Botar, A. A.; Barabas, A.; Oprean, I.; Hodosan, F.
Journal fuer Praktische Chemie (Leipzig), 1983 , vol. 325, # 1 p. 17 - 26
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) 1.) ether, 12 h, room temp., 2.) 80 deg C, 15 h; Yield given. Multistep reaction;
参考文献
Fiandanese, Vito; Marchese, Giuseppe; Naso, Francesco; Ronzini, Ludovico
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1115 - 1120
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) 1.) ether, 12 h, room temp., 2.) 80 deg C, 15 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Fiandanese, Vito; Marchese, Giuseppe; Naso, Francesco; Ronzini, Ludovico
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1115 - 1120
