5-(羟甲基)-[2,2]-联噻吩合成路线 （共 9 条）
反应条件
sodium borohydride in methanol
参考文献
Purdue Research Foundation; International Technology Research Institute
Patent: US5578636 A1, 1996 ;
反应条件
1: 2-(thien-2-yl)thiophene With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 3.5 h; 2: paraformaldehyde in tetrahydrofuran; hexanes T=20°C; 18 h;
参考文献
MERCK and CO., INC.
Patent: WO2003/101381 A2, 2003 ;
Location in patent: Page 49, 50 ;
WO 03/101381 A2
反应条件
1: 2-(thien-2-yl)thiophene With n-butyllithium in tetrahydrofuran T=-78°C; 2: formaldehyd in tetrahydrofuran
参考文献
Shao, Pengchang P.; Ok, Dong; Fisher, Michael H.; Garcia, Maria L.; Kaczorowski, Gregory J.; Li, Chunshi; Lyons, Kathryn A.; Martin, William J.; Meinke, Peter T.; Priest, Birgit T.; Smith, McHardy M.; Wyvratt, Matthew J.; Ye, Feng; Parsons, William H.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1901 - 1907
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=60°C; 16 h;
参考文献
Crisp, Geoffrey T.
Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 307 - 316
反应条件
1: 1.) LDA / 1.) THF, from -78 to 0 deg C, 1.5 h, 2.) from -78 deg C to RT, 3.5 h 2: 98 percent / NaBH4 / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Xu, Wei-Chu; Zhou, Qin; Ashendel, Curtis L.; Chang, Ching-Te; Chang, Ching-Jer
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2279 - 2282
反应条件
HAuCl4*3H2O in water T=20°C; 6 h;
参考文献
Hong, Jin-Hyung; Hwang, Yong-Kyung; Hong, Jin-Yeon; Kim, Hee-Jin; Kim, Sung-Jin; Won, Yong Sun; Huh, Seong
Chemical Communications, 2011 , vol. 47, # 24 p. 6963 - 6965
反应条件
1.1: magnesium / tetrahydrofuran / Inert atmosphere; Reflux 1.3: Cooling with ice 2.1: sodium tetrahydroborate; methanol / Inert atmosphere View Scheme
参考文献
Deng, Huayun; Fang, Ye; He, Mingqian; Hu, Haibei; Niu, Weijun; Sun, Haiyan
Patent: US2012/22116 A1, 2012 ;
反应条件
in neat (no solvent) 2 h; Irradiation;
参考文献
Krishnaswamy, N. R.; Kumar, Ch. Siva Sai Kamana; Prasanna, S.
Journal of Chemical Research, Miniprint, 1991 , # 7 p. 1801 - 1830
反应条件
1: Zn(N3)2*Py; DPPA; DBU / CH2Cl2 / 20 °C 2: PPh3; H2O / tetrahydrofuran View Scheme
参考文献
Shao, Pengchang P.; Ok, Dong; Fisher, Michael H.; Garcia, Maria L.; Kaczorowski, Gregory J.; Li, Chunshi; Lyons, Kathryn A.; Martin, William J.; Meinke, Peter T.; Priest, Birgit T.; Smith, McHardy M.; Wyvratt, Matthew J.; Ye, Feng; Parsons, William H.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1901 - 1907
