3-(哌啶-4-基甲基)-1H-吲哚合成路线 （共 7 条）
反应条件
1: With hydrogen; acetic acid; platinum(IV) oxide T=20°C; P=1551.49 Torr; 2 h; 2: With sodium carbonate in water; ethyl acetate
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
Location in patent: Page/Page column 41-42 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) 20 deg C, 3 h, 2.) reflux, 15 min;
参考文献
Gueremy, Claude; Audiau, Francois; Champseix, Alain; Uzan, Andre; Fur, Gerard Le; Rataud, Jean
Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1306 - 1310
反应条件
ethanol; acetic acid Hydrogenation;
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
反应条件
2: platinum; acetic acid / Hydrogenation View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
反应条件
1: 1.) MeMgI / 1.) Et2O, reflux, 2 h, 2.) Et2O, toluene, RT, overnight 2: 5 N HCl / ethanol / 4 h / Heating 3: 52 percent / LiAlH4 / tetrahydrofuran / 1.) 20 deg C, 3 h, 2.) reflux, 15 min View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/152243 A1, 2011 ;
参考文献
Gray
Journal of Organic Chemistry, 1958 , vol. 23, p. 1453
反应条件
chloroform
Behandeln des Reaktionsprodukts mit LiAlH4 in Dioxan;
参考文献
Bader; Oroshnik
Journal of the American Chemical Society, 1959 , vol. 81, p. 163,166
